Evaluation of the Changes in Some Hematological and Immunological Parameters in Patients with Rheumatoid Arthritis
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Abstract
Rheumatoid arthritis [RA] is a persistent inflammatory polyarthritis condition characterized by distinct immunological, clinical, genetic, and pathological characteristics, as well as remissions and exacerbations. This study was designed to estimate some Haematological and immunological parameters of Iraqi patients with RA. The data were collected between August 2023 and May 2024 from a total of 60 patients and 30 healthy controls. A serological test was assessed, including erythrocyte precipitation rate, and CRP. Complete blood count was measured using a fully automated quantitative Samsung device. The levels of IL-1β, IL-2, IL-4, IL-10 cytokines were assessed by sandwich ELISA. The result of this study showed that most RA patients were female compared to males. The levels of RF, CRP, and ESR test were significantly higher in patients with RA compared to the control group. RA patients showed statistically significant higher in WBC and Ptt tests while they had lower RBCs, Hb, and RDW compared to controls. When compared to healthy individuals, we observed that patients with RF had greater levels of cytokines IL-1β, IL-2, IL-4, and IL-10. RF patients had higher levels of IL-1β, IL-2, IL-4, and IL-10 than did healthy people.
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